Renin-dependent hypertension in polyarteritis nodosa.

The renin–angiotensin system as a primary cause of polyarteritis nodosa in rats

Polyarteritis nodosa is a necrotizing vasculitis of medium-sized arteries of unknown origin. Hypertension is present in 30% of patients with polyarteritis nodosa. In those cases, high renin levels are thought to be secondary to renal involvement. The present study was performed to identify causal factors of polyarteritis nodosa. In cyp1a1ren-2 transgenic rats, vasculitis of medium-sized arterie...

Pathogenesis of polyarteritis nodosa in hypertensive rats.

The pathogenesis of the vascular lesions of polyarteritis nodosa found in young rats with experimental renal hypertension is described. The panarteritic lesion was a product of the combination of renal injury and feeding sodium chloride. It began with a fibrinoid necrosis of the intima and media which was followed by an extensive inflammatory reaction with subsequent fibrosis of all layers of t...

Effect of diet on experimental hypertension and on the development of polyarteritis nodosa in rats.

Childhood polyarteritis nodosa: a clinical diagnosis.

A six-year old boy presented with dry gangrene of toes and fingers with hypertension with no other systemic abnormalities. He had persistently high inflammatory parameters, was diagnosed as childhood classic polyarteritis nodosa and showed improvement with immunosuppressants along with antihypertensives. Toe gangrene required amputation in view of superadded infection.

Combination of interferon alpha and ribavirin in the treatment of hepatitis C: implications for the clinical nephrologist.

Adjuvant medical treatment steroid therapy of polyarteritis nodosa. Specific treatments are sometimes required. 55: 146–155 renal vasculitis. Angiotensin converting enzyme inhib-10. Guillevin L, Jarrousse B, Lok C et al. Long-term followup after itors or angiotensin II-receptor blockers are effective treatment of polyarteritis nodosa and Churg–Strauss angiitis and able to control severe or mali...